The natural history of the metabolic syndrome is marked by progression from endocrine and metabolic perturbations \r\nto overt diabetes, hypertension, secondary complications of nephropathy, neuropathy and retinopathy; along with \r\nserious comorbidities such as vascular disorders and cancers of the colon, breast, ovary and prostate gland. Here, \r\nwe report four case studies involving patients with suboptimal control of metabolic factors treated with an integrated \r\nregimen of lipid-modifying agents, pleiotropic botanical medicine and lifestyle intervention. Over the course of 7 to 13 \r\nmonths, striking improvements to the triad of fasting plasma glucose, blood pressure, lipid profile were observed; with \r\nconcomitant stabilisation of the body mass index and body fat percentage.\r\nOur results proffer early clinical evidence that hormonal and metabolic competency can be restored, and \r\nprogression of the metabolic syndrome arrested, through use of polyvalent pharmacotherapy to enable less intrusive \r\nlifestyle changes ââ?¬â?? without requiring significant weight loss which notably, conferred more effective and sustained \r\ncontrol over the constellation of lipemia, glycemia, arterial tension, atherogenicity and adipo-obesity.
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